超级病毒“金美拉”和抗生素在运送途中，被恐怖组织头目Sean Ambrose（ Dougray Scott 饰）盗走，Ethan Hunt（Tom Cruise 饰）率领他的IMF小组接受中情局的任务，找回病毒。这次，Ethan Hunt找到了女飞贼Nyah Nordoff-Hall（Thandie Newton 饰）搭档，后者是Sean Ambrose的前女友。Ethan Hunt在获取Nyah信任的同时，二人也暗生情愫。但是，为了完成任务，Ethan Hunt不得不安排Nyah回到Sean Ambrose身边卧底。Nyah终于打探出病毒所在的药厂，接获情报的Ethan Hunt前往药厂准备销毁病毒；另一边，Sean Ambrose已经察觉出了Nyah回到自己身边的真正目的，组织人马在药厂等待Ethan Hunt自投罗网。激烈的搏斗中，Nyah为了帮助Ethan Hunt完成任务，将病毒注入了自己体内，只有在20个小时之内将抗生素注入Nyah体内，才能挽救她的性命，Ethan Hunt又将面临不可能的任务。

超级病毒“金美拉”和抗生素在运送途中，被恐怖组织头目Sean Ambrose（ Dougray Scott 饰）盗走，Ethan Hunt（Tom Cruise 饰）率领他的IMF小组接受中情局的任务，找回病毒。 这次，Ethan Hunt找到了女飞贼Nyah Nordoff-Hall（Thandie Newton 饰）搭档，后者是Sean Ambrose的前女友。Ethan Hunt在获取Nyah信任的同时，二人也暗生情愫。 但是，为了完成任务，Ethan Hunt不得不安排Nyah回到Sean Ambrose身边卧底。 Nyah终于打探出病毒所在的药厂，接获情报的Ethan Hunt前往药厂准备销毁病毒；另一边，Sean Ambrose已经察觉出了Nyah回到自己身边的真正目的，组织人马在药厂等待Ethan Hunt自投罗网。 激烈的搏斗中，Nyah为了帮助Ethan Hunt完成任务，将病毒注入了自己体内，只有在20个小时之内将抗生素注入Nyah体内，才能挽救她的性命，Ethan Hunt又将面临不可能的任务。

Former marine JJ Chalmers gives a unique perspective on the evacuation of Dunkirk.

Premier Pavel Zagov's death has been covered up by Deputy Premier Gregor Kamirov. He is using an actor to take Zagov's place, and endorse Kamirov as his successor.

The team is sent to stop a criminal who has obtained information on high ranking government officials that the Syndicate can use to coerce them. So they use the man's eagerness to be the new head of the Syndicate and a rival's dislike for him to get him.

Kruger Schtelman an ex-SS officer serving time in a communist prison is kidnapped by the IMF and made to believe he is on board a submarine. The team must get Schtelman to reveal the location of funds stolen by the Nazis before the military police close in on the IMF operation.

An enemy nation has hijacked a US supported revolutionary movement trying to overturn a dictatorship. The IMF posses as a religious organization seeking the release of the priest who is the true leader of the revolution.

Cinnamon goes undercover as a sexy nightclub entertainer to expose a homicidal bureaucrat, and eliminate his ruthless rival.

Anton Valdas, the highest ranking intelligence agent for an enemy power, is believed to possess a master list of Western agents who have defected to his government. Jim Phelps and Rollin Hand take on the mission of retrieving the list.